产品货号：
GS4544
中文名称：
重组人sFasR/TNFRSF6
英文名称：
Recombinant Human soluble Fas Receptor/TNFRSF6
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.6kDa,a single non-glycosylated polypeptide chain containing 157 amino acids.
储存条件：冷冻（-20℃）
概述
Fas and Fas Ligand(FasL)belong to the TNF superfamily and are type I and type II transmembrane proteins,respectively.Binding of FasL to Fas triggers apoptosis in Fas-bearing cells.The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms.These active caspases then cleave various cellular substrates leading to the eventual cell death.sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人sFasR/TNFRSF6，sFasR/TNFRSF6, Human，Recombinant Human soluble Fas Receptor/TNFRSF6
储存条件：冷冻（-20℃）
概述
Fas and Fas Ligand(FasL)belong to the TNF superfamily and are type I and type II transmembrane proteins,respectively.Binding of FasL to Fas triggers apoptosis in Fas-bearing cells.The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms.These active caspases then cleave various cellular substrates leading to the eventual cell death.sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10-15μg/ml in the presence of 2ng/ml of rHuFas Ligand. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHusFasR/TNFRSF6 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVN GDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCN STVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN |
相关搜索：重组人sFasR/TNFRSF6，sFasR/TNFRSF6, Human，Recombinant Human soluble Fas Receptor/TNFRSF6